CENTD - 02/11/2018
Post-Doctoral Research Fellow: São Paulo, Brazil
Project Title: Signaling pathways involved in the inflammatory response in 3D culture models of osteoarthritis
The Centre of Excellence for Research in Target Discovery, a new partnership among FAPESP, Glaxo-Smith Kline and Butantan Institute, has a postdoctoral position available in the Laboratory of Immunochemistry at Butantan Institute, Sao Paulo, Brazil.
The postdoctoral fellow will have the opportunity to work with a project on the identification/elucidation and validation of novel targets/pathways involved in osteoarthritis, using as tools toxins from poisonous animals.
As requirements, the candidates should have PhD in Immunology, at least three first author papers in international peer reviewed journals, motivation to solve complex biological problems in the field of target discovery and to productively working in an interdisciplinary environment and be fluent in English with good writing skills.
Good experience in 3-D cultures and in immunological techniques, including multi-color flow cytometry are essential skills required for the candidates. Experience in molecular biology and bioinformatics is desired.
Interested applicants should submit an application including a cover letter outlining research accomplishments, CV, two recommendation letters. Please send the application to Denise V Tambourgi, PhD (email@example.com).
This opportunity is open to candidates of any nationalities. The selected candidate will receive a FAPESP's Post-Doctoral fellowship in the amount of R$ 7.373,10 (around 2,115.00 USD) monthly and a research contingency fund, equivalent to 15% of the annual value of the fellowship which should be spent in items directly related to the research activity.
Installation financial assistance:
Those who need to move to the city where is located the headquarters of the research institution may request the benefit Installation financial assistance, comprising:
One (1) additional monthly fee to be paid along with the first month of the fellowship;
Transportation costs, if any displacement by distance exceeding 350 km -see http://www.fapesp.br/en/5427
Deadline for applications: February, 28, 2019
Starting date: April, 02, 2019
Grant: 2015/50040-4, São Paulo Research Foundation (FAPESP)
The inflammatory response involved in osteoarthritis will be studied in 3D culture models. This model allows to closely reproducing the microenvironment of the joints, once different cell types can be co-cultured, such as chondrocytes, osteocytes and fibroblasts. Immune cells can also be added to these models, allowing the study of their roles on the pathogenesis of osteoarthritis. Cultures will be stimulated by toxins isolated from different venomous animals, whose pro-inflammatory activities had been previously described, and the expression and production of molecules involved with inflammation will be evaluated.
After this initial in vitro screening, some toxins will be chosen for better elucidate the signaling pathways triggered in the different cell types present in the 3D culture. The study of signaling pathways will involve different assays, such as the use of specific inhibitors and the intracellular staining of signaling molecules, which will be analyzed by multicolor flow cytometry and confocal microscopy, including co-localization and tracking assays. These studies will enable the identification of novel signaling molecules involved with the inflammatory response, possibly novel targets for the development of anti-inflammatory drugs specific for the treatment of osteoarthritis.
Butantan Institute - 08/22/2018
TT-IVA: Graduated, 2 years of experience in WEB development and / or server administration - TT 4 scholarship, for graduated, Information Technology (IT) specialist, with two years of undergraduate experience or a master's degree in IT, unemployed, to dedicate 16 to 40 hours a week (the value of the scholarship to be paid will be proportional to the number of weekly hours) to the activities supporting the research project. Valid for 12 months.
Value: R$ 5.087,20
TT-3: Graduated / with no experience but with an academic background - Scholarship TT-3, for university graduated students, with no reprobation in their academic history and unemployed, to dedicate 16 to 40 hours weekly (the value of the Scholarship to be paid will be proportional to the number of weekly hours) to the activities supporting the research project. The period of the TT-3 scholarship will be deducted in case the candidate receives a Master's or Direct Doctorate Scholarship. Valid for 12 months.
Value: R$ 1.228,40
- WEB development (start a gateway of scientific results)
- LINUX server administration (ubuntu) - basic (not advanced)
Send an email to firstname.lastname@example.org
Instituto Butantan - 06/29/2018
Post Doc Vacancies - Apply by July 30th Three postdoctoral fellowships are offered by the Centre of Excellence in New Target Discovery (CENTD) of the Butantan Institute. Registration is open and the application deadline ends on July 30, 2018.
PD Scholarship in Cell and Molecular Biology
PD Scholarship in Molecular Biology
PD Scholarship in Systems Biology and Biostatistics
Interested candidates should apply for registration through the email of Dr. Ana Marisa Chudzinski Tavassi (email@example.com; firstname.lastname@example.org). The documents should contain: a cover letter describing research accomplishments, curriculum vitae and two letters of recommendation.
The monthly value of the Post-Doctoral Fellowship of FAPESP, for those contemplated, will be R$7,174.80 per month and a research fund, equivalent to 15% of the annual value of the scholarship and which should be spent on items directly related to research activities.
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