Postdoctoral Fellowship in Molecular Biology

CENTD - 25/08/2022

The Centre of Excellence in New Target Discovery (CENTD), a partnership between FAPESP, Glaxo-SmithKline (GSK) and the Butantan Institute, is offering a FAPESP Post-Doctoral scholarship, available for immediate start.

The fellow will have the opportunity to work on the identification and characterization of new molecular targets identified in cellular models using multiple approaches. In this process, cells are subjected to various stimuli and then treated with potentially anti-inflammatory synthetic peptides. Targets are identified by chemoproteomic strategies.

The fellow will focus primarily on validating the identified targets with the use of genomic editing techniques such as CRISPR/Cas9 (gene knockout), RNAi gene silencing (knockdown) and/or overexpression of genes of interest.

Candidates must have a PhD in Biochemistry, Molecular Biology or related areas, good scientific output with publications as first author in the area of expertise that are compatible with the position, motivation to solve complex biological problems in the field of molecular target discovery, and the hability to work in an interdisciplinary environment. Excellent organizational skills with experience in planning and developing experiments, a proactive mindset, Independence and group work are essential. In addition, the candidate must have good communication skills in English, for drafting scientific manuscripts and orally presenting/discussing results at regular meetings with the participation of GSK.

Applications must be sent to the following e-mail addresses: centd.vagas@butantan.gov.br and ana.chudzinski@butantan.gov.br.

Registration start: 08/25/2022
Deadline for applications: 09/25/2022
Duration: 48 months.
Grant: 2020/13139-0, FAPESP.

For more information about the job position, please see the link below:
Document

     

Postdoctoral fellowship in Molecular Biology

CENTD - 22/12/2021

The candidate will have the opportunity to work in target identification and validation of anti-inflammatory peptides, applying mass-spectrometry based proteomic techniques.

Interested candidates must apply for the position, presenting an introduction letter describing the scientific research accomplishments, curriculum vitae and two recommendation letters. Please, send the application to Dra. Ana Marisa Chudzinski Tavassi (centd.vagas@butantan.gov.br; ana.chudzinski@butantan.gov.br).

The position is available to Brazilian and foreigners. The selected candidate will receive a postdoctoral fellowship for R$ 7,373.10 monthly and Technical Reserve equivalent to 10% of the annual fellowship amount to cover the expenses related to the research activity.

Those who need to move to the city where the research institution’s headquarters is located may request the benefit of financial assistance for installation, comprising:

- One (1) additional fee to be paid along with the first month of the fellowship;
- Transport costs, if there is a distance greater than 350km (visit www.fapesp.br/en/5427).

Registration start: 12/15/2021
Deadline for applications: 01/15/2022
Duration: 4 years.
Grant: 2020/13139-0, FAPESP.

For more information about the job position, please see the link below:
Document

     

Post-Doctoral Research Fellow

CENTD - 24/06/2020

The applicant will work with multidisciplinary teams for the identification of inflammatory events triggered by SARS-CoV-2, in different cell models, and the regulation of these events by the use of molecules derived from animal secretions, potentially antiviral drugs, monoclonal antibodies and mesenchymal stem cells. Requirements: Ph.D. in Biochemistry, Virology or related field, with at least 3 articles as the first author in international journals, motivation to solve complex biological problems in the field of cell biology/virology, motivation to work in an interdisciplinary environment, fluency in English with good writing ability. Proven experience in cell and virus culture, classic virology methods, cell and molecular biology techniques, and analysis of immunological/pharmacological aspects are desirable requirements. Registration: a cover letter describing research achievements, curriculum vitae and 2 recommendation letters should be sent to Dr. Ana Marisa Chudzinski-Tavassi (centd@butantan.gov.br; ana.chudzinski@butantan.gov.br). This application covers all nationalities. The selected candidate will receive a Post-Doctoral grant from FAPESP, in the amount of R $ 7,373.10 per month and an additional support of 15% of the annual value of the scholarship, which must be spent on items related to the project. The scholarship period is 2 years.

Researcher: Ana Marisa Chudzinski-Tavassi
Coordinator Unit: Centre of Excellence for Research in Target Discovery / Instituto Butantan
Type: 1. Post doctoral
knowledge area: 19
registration date: 10/07/2020
Number of Vacancies: 01
City: Instituto Butantan - São Paulo - SP
Cep: 05503-900
Address: Av. Vital Brasil, 1500 - Butantã, São Paulo - SP

     

Information Technology (IT) Specialist

CENTD - 05/07/2019

TT4 tasks which will be supported by the bioinformatics team.

a) Development of a portal to document experiments and results.
- Primary entries: equipment, organisms, cell types, etc.
- Experiments registration.
- Texts: experiments versus description, equipment, standards, standardized results, etc.
- Results of experiments:
spreadsheets, values, images, texts and videos.

b) Development of a database.
c) Development of the WEB interface in python, HTML, or R. with security levels and information access.
d) Linux server basic administration.

- Graduated in Computer Science or relative.
- Minimum one year of proven web development experience.

Send resume to: centd.vagas@butantan.gov.br

     

Post-Doctoral Research Fellow

CENTD - 02/11/2018

Post-Doctoral Research Fellow: São Paulo, Brazil

Project Title: Signaling pathways involved in the inflammatory response in 3D culture models of osteoarthritis

The Centre of Excellence for Research in Target Discovery, a new partnership among FAPESP, Glaxo-Smith Kline and Butantan Institute, has a postdoctoral position available in the Laboratory of Immunochemistry at Butantan Institute, Sao Paulo, Brazil.

The postdoctoral fellow will have the opportunity to work with a project on the identification/elucidation and validation of novel targets/pathways involved in osteoarthritis, using as tools toxins from poisonous animals.

As requirements, the candidates should have PhD in Immunology, at least three first author papers in international peer reviewed journals, motivation to solve complex biological problems in the field of target discovery and to productively working in an interdisciplinary environment and be fluent in English with good writing skills.

Good experience in 3-D cultures and in immunological techniques, including multi-color flow cytometry are essential skills required for the candidates. Experience in molecular biology and bioinformatics is desired.

Interested applicants should submit an application including a cover letter outlining research accomplishments, CV, two recommendation letters. Please send the application to Denise V Tambourgi, PhD (denise.tambourgi@butantan.gov.br).

This opportunity is open to candidates of any nationalities. The selected candidate will receive a FAPESP's Post-Doctoral fellowship in the amount of R$ 7.373,10 (around 2,115.00 USD) monthly and a research contingency fund, equivalent to 15% of the annual value of the fellowship which should be spent in items directly related to the research activity.

Installation financial assistance:

Those who need to move to the city where is located the headquarters of the research institution may request the benefit Installation financial assistance, comprising:

One (1) additional monthly fee to be paid along with the first month of the fellowship;

Transportation costs, if any displacement by distance exceeding 350 km -see http://www.fapesp.br/en/5427

Deadline for applications: February, 28, 2019

Starting date: April, 02, 2019

Grant: 2015/50040-4, São Paulo Research Foundation (FAPESP)

Project

The inflammatory response involved in osteoarthritis will be studied in 3D culture models. This model allows to closely reproducing the microenvironment of the joints, once different cell types can be co-cultured, such as chondrocytes, osteocytes and fibroblasts. Immune cells can also be added to these models, allowing the study of their roles on the pathogenesis of osteoarthritis. Cultures will be stimulated by toxins isolated from different venomous animals, whose pro-inflammatory activities had been previously described, and the expression and production of molecules involved with inflammation will be evaluated.

After this initial in vitro screening, some toxins will be chosen for better elucidate the signaling pathways triggered in the different cell types present in the 3D culture. The study of signaling pathways will involve different assays, such as the use of specific inhibitors and the intracellular staining of signaling molecules, which will be analyzed by multicolor flow cytometry and confocal microscopy, including co-localization and tracking assays. These studies will enable the identification of novel signaling molecules involved with the inflammatory response, possibly novel targets for the development of anti-inflammatory drugs specific for the treatment of osteoarthritis.

     

FAPESP scholarship opportunities

Butantan Institute - 08/22/2018

TT-IVA: Graduated, 2 years of experience in WEB development and / or server administration - TT 4 scholarship, for graduated, Information Technology (IT) specialist, with two years of undergraduate experience or a master's degree in IT, unemployed, to dedicate 16 to 40 hours a week (the value of the scholarship to be paid will be proportional to the number of weekly hours) to the activities supporting the research project. Valid for 12 months.
Value: R$ 5.087,20

TT-3: Graduated / with no experience but with an academic background - Scholarship TT-3, for university graduated students, with no reprobation in their academic history and unemployed, to dedicate 16 to 40 hours weekly (the value of the Scholarship to be paid will be proportional to the number of weekly hours) to the activities supporting the research project. The period of the TT-3 scholarship will be deducted in case the candidate receives a Master's or Direct Doctorate Scholarship. Valid for 12 months.
Value: R$ 1.228,40

Job:
- WEB development (start a gateway of scientific results)
- LINUX server administration (ubuntu) - basic (not advanced)

Send an email to centd.vagas@butantan.gov.br

     

Post Doc Vacancies - Apply by July 30^th

Instituto Butantan - 06/29/2018

Post Doc Vacancies - Apply by July 30^th Three postdoctoral fellowships are offered by the Centre of Excellence in New Target Discovery (CENTD) of the Butantan Institute. Registration is open and the application deadline ends on July 30, 2018.

They are:
PD Scholarship in Cell and Molecular Biology
PD Scholarship in Molecular Biology
PD Scholarship in Systems Biology and Biostatistics

Interested candidates should apply for registration through the email of Dr. Ana Marisa Chudzinski Tavassi (centd@butantan.gov.br; ana.tavassi@butantan.gov.br). The documents should contain: a cover letter describing research accomplishments, curriculum vitae and two letters of recommendation.

The monthly value of the Post-Doctoral Fellowship of FAPESP, for those contemplated, will be R$7,174.80 per month and a research fund, equivalent to 15% of the annual value of the scholarship and which should be spent on items directly related to research activities.

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