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Publicações

2020
Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model. Flavio Lichtenstein, Asif Iqbal, Sonia Elisabete Alves de Lima Will, Rosemary Viola Bosch, Carlos DeOcesano-Pereira, Mauricio Barbugiani Goldfeder, Roger Chammas, Carlos Eduardo Madureira Trufen, Katia Luciano Pereira Morais, Jean Gabriel de Souza, Renato Jose Mendonça Natalino, Inacio Junqueira de Azevedo, Milton Yutaka Nishiyama Junior, Ursula Oliveira, Francisco Ivanio Arruda Alves, Jaqueline Mayara Araujo, Aline Ramos Maia Lobba & Ana Marisa Chudzinski-Tavassi. Scientific Reports volume 10, Article number: 6388 (2020)

Murine osteoclastogenesis suppression using conditioned media produced by melanoma or activated and non-activated Jurkat-E6 cells. Mambelli-Lisboa NC, Frare EO, da Costa-Neves A, Prieto da Silva ÁRB, Kerkis I. Cell Biol Int. 2020;44(5):1184‐1192. doi:10.1002/cbin.11317

Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. Carlos DeOcesano-Pereira, Raquel A C Machado, Ana Marisa Chudzinski-Tavassi, Mari Cleide Sogayar. Int J Mol Sci. 2020 Apr 9;21(7):2611. doi: 10.3390/ijms21072611.

A Representative Metalloprotease Induces PGE 2 Synthesis in Fibroblast-Like Synoviocytes via the NF-κB/COX-2 Pathway With Amplification by IL-1β and the EP4 Receptor Mariana N Viana, Elbio Leiguez, José M Gutiérrez, Alexandra Rucavado, Regina P Markus, Marina Marçola, Catarina Teixeira, Cristina M Fernandes Sci Rep. 2020 Feb 24;10(1):3269. doi: 10.1038/s41598-020-59095-z.

2019
Bufalo, MC et al. Advanced glycation endproducts produced by in vitro glycation of type I collagen modulate the functional and secretory behavior of dorsal root ganglion cells cultivated in two-dimensional system. Experimental Cell Research. 382 (2): 111475, 2019, doi: 10.1016/j.yexcr.2019.06.020. (PID7)

Maria DA, Will SEAL, Bosch RV, Souza JG, Sciani JM, Goldfeder MB, Rondon GG, Chudzinski-Tavassi AM. Preclinical evaluation of Amblyomin-X, a Kunitz-type protease inhibitor with antitumor activity. Toxicol Rep. 2018 Dec 1;6:51-63. doi: 10.1016/j.toxrep.2018.11.014. eCollection 2019 (PQW2)

Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):111-120. doi: 10.1007/s13318-018-0500-z (PQW2)

Chudzinski-Tavassi, AM; Teixeira, CFP; Tambourgi, DV ; Kerkis, I; Batista, IFB ; Martinhez OCI; Cury Y. Centre of Excellence in New Target Discovery (CENTD): new approach to inflammatory molecular targets and signaling pathways identification. TOXICON, 2019. https://doi.org/10.1016/j.toxicon.2019.06.161

Batista, IFC; Trufen, CEM; Souza, JG; Marques-Porto, R; Portas, VB; Jared, C; Chudzinski-Tavassi, AM. Centre of Excellence in New Target Discovery: a Biobank establishment. TOXICON, 2019. https://doi.org/10.1016/j.toxicon.2019.06.160 (BIOB)

Teixeira, CFP; Fernandes, CM; Leiguez, E and Chudzinski-Tavassi AM. Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation. Front Immunol., 10: 2082, 2019. doi: 10.3389/fimmu.2019.02082

Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. J. Neurochemistry. 2019 Jan;148(1):80-96. (PQW4)

Pavon LF, Capper D, Sibov TT, de Toledo SRC, Thomale UW, de Souza JG, Cabral FR, Berra CM, Silva da Costa MD, Mendonça Niçacio J, Dastoli PA, de Oliveira DM, Malheiros SMF, da Cruz EF, Malheiros JM, de Oliveira SM, Silva NS, Petrilli AS, Cappellano AM, Brunialti MC, Salomão R, de Paiva Neto MA, Chudzinski-Tavassi AM, Cavalheiro S. New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X. Sci Rep. 2019 Jul 10;9(1):9973. doi: 10.1038/s41598-019-45799-4

Priscila Silva Cunegundes, Jean Gabriel De Souza, Douglas Souza Oliveira, Ana Marisa Chudzinski-Tavassi. A new differentiation method for THP-1-Derived Dendritic cells, TOXICON, 2019. https://doi.org/10.1016/j.toxicon.2019.06.164

de Souza, J. G.; Jensen, J. R.; Starobinas, N.; Monteleone L.F; Cabrera, W.H.; Ibañez, O.C. Pycard gene Polymorphism and pristane induced Arthritis in mice selected for acute inflammatory response. Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2019.02.381. (PQW5)

F.B. Dias de Oliveira; E. Antoniolli; J.G. Souza; O.F. Metropolo Dias; M. Ferretti. Mesenchymal stromal cells tracking and cytokines kinetics following intra-articular and intravenous transplantation. Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2019.02.315. (PQW5)

F.B. Dias de Oliveira; J.G. Souza; O. Furiama; M. Ferretti; E. Antoniolli. Imaging and functional assessment of medial meniscus surgical destabilization animal model for osteoarthritis. Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2018.02.889(PQW5)

Sibov TT, Pavon LF, Cabral FR, Cunha IF, De Oliveira DM, De Souza JG, Marti LC, Da Cruz EF, Malheiros JM, Paiva FF, Tannús A, De Oliveira SM, Da Costa MDS, Dastoli PA, Mendonça JN, De Toledo SRC, Malheiros SMF, De Paiva Neto MA, Rego NBB, Moron AF, Cavalheiro S. Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke. Cell Transplant. 2019 Jun 4:963689719854342. doi: 10.1177/0963689719854342 (PQW5)

Pavon LF, Sibov TT, de Souza AV, da Cruz EF, Malheiros SMF, Cabral FR, de Souza JG, Boufleur P, de Oliveira DM, de Toledo SRC, Marti LC, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, Chudzinski-Tavassi AM, de Paiva Neto MA, Cavalheiro S. Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo. Stem Cell Res Ther. 2018 Nov 9;9(1):310. doi: 10.1186/s13287-018-1049-0.

de Carvalho LR, Borrego A, Jensen JR, Cabrera WHK, Santos AM, Ribeiro OG, Starobinas N, De Franco M, Dragani TA, Manenti G, Ibañez OCM. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response. J Immunol Res. 2019 Mar 31;2019:5298792. doi: 10.1155/2019/5298792. eCollection 2019. (PQW5)

Rossato C, Albuquerque LL, Katz ISS, Borrego A, Cabrera WHK, Spadafora-Ferreira M, Ribeiro OG, Starobinas N, Ibañez OM, De Franco M, Jensen JR. Early Peritoneal CC Chemokine Production Correlates with Divergent Inflammatory Phenotypes and Susceptibility to Experimental Arthritis in Mice. J Immunol Res. 2019 Feb 26;2019:2641098. doi: 10.1155/2019/2641098. eCollection 2019. (PQW5)

Borrego A, Cabrera WHK, Jensen JR, Correa M, Ribeiro OG, Starobinas N, De Franco M, Pettinicchio A, Dragani TA, Ibañez OCM, Manenti G. Germline control of somatic Kras mutations in mouse lung tumors. Mol Carcinog. 2018 Jun;57(6):745-751. doi: 10.1002/mc.22796. (PQW5)

Fernandes JG, Borrego A, Jensen JR, Cabrera WHK, Correa MA, Starobinas N, Ribeiro OG, Ibañez OM, De Franco M. miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. J Immunol Res. 2018 Dec 16;2018:1928405. doi:10.1155/2018/1928405. eCollection 2018. (PQW5)

2018
Villas-Boas IM, Bonfá G, Tambourgi D V. Venomous caterpillars: From inoculation apparatus to venom composition and envenomation. Toxicon. 2018; 153:39–52. DOI: 10.1016/j.toxicon.2018.08.007.

Mambelli-Lisboa NC, Mozer Sciani J, Rossan Brandão Prieto da Silva A, Kerkis I. Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells. Molecules. 2018. 20;23 (4).

Bufalo, MC; Almeida, MES; Zambelli, VO; Sampaio, SC; Sant’Anna, MB; Kimura, LF; Giardini, AC; Cury, Y“Glycated collagen induces pro-inflammatory factors activation on rat dorsal root ganglion (DRG) primary culture” in the Third International Symposium on Inflammatory Diseases – INFLAMMA III. From June 21th to 23th, 2017; 20 hours, Ribeirão Preto - SP.

Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintainance of monocarboxylate transporter MCT2 protein levels. J. Neurochemistry. Accepted, 2018.

Chudzinski-Tavassi AM, Faria F, Alvarez-Flores MP. Anticoagulants from Hematophagous. In: Anticoagulant Drugs. Edited by Bozic-Mijovski M. ISBN 978-1-78923-622-4. DOI: 10.5772/intechopen.78025, p. 39-61, 2018.

Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells.Schmidt MCB, Morais KLP, Almeida MES, Iqbal A, Goldfeder MB, Chudzinski-Tavassi AM. Cell Adh Migr. 2018 Sep 25:1-10. doi: 10.1080/19336918.2018.1516982. [Epub ahead of print] PMID: 30238848

Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Eur J Drug Metab Pharmacokinet. 2018 Aug 21. doi: 10.1007/s13318-018-0500-z. [Epub ahead of print]. PMID: 30132264

Chudzinski-Tavassi AM, Morais KLP, de Souza JG, Chammas R. Role of Immune System in Kidney Cancer. Edited by Sashi S. Kommu. ISBN 978-953-51-5910-0. 2018.

2017
Iqbal A, Goldfeder MB, Marques-Porto R, Asif H, Souza JG, Faria F, Chudzinski-Tavassi AM. Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin. Sci Rep. 2017 May 3;7(1):1431. doi: 10.1038/s41598-017-01486-w.

Kerkis I, de Brandão Prieto da Silva AR, Pompeia C, Tytgat J, de Sá Junior PL. Toxin bioportides: exploring toxin biological activity and multifunctionality. Cell Mol Life Sci. 2017 Feb;74(4):647-661. doi: 10.1007/s00018-016-2343-6.

2016
Branco VG, Iqbal A, Alvarez-Flores MP, Sciani JM, de Andrade SA, Iwai LK, Serrano SM, Chudzinski-Tavassi AM. Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo. Biochim Biophys Acta. 2016 Oct;1864(10):1428-35. doi: 10.1016/j.bbapap.2016.07.011.

de Souza JG, Morais KL, Anglés-Cano E, Boufleur P, de Mello ES, Maria DA, Origassa CS, de Campos Zampolli H, Câmara NO, Berra CM, Bosch RV, Chudzinski-Tavassi AM. Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model. Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11555

     

A guerra contra o câncer no Brasil - Carlos Henrique Fioravant

Instituto Butantan - 15/10/2019


A guerra contra o câncer no Brasil - Carlos Henrique Fioravant

A obra "A Guerra contra o câncer no Brasil" da editora Atheneu mostra que os homens da ciência médica são tradutores de seu tempo, quando olham para as possibilidades de intervir no corpo individual e social para diminuir sofrimentos e encontrar os males que assolam a população.

SINOPSE

Antes era fácil-fácil demais- levar uma molécula nova para testes em hospitais. Agora, a engrenagem entre centros de pesquisa, hospitais, empresas e governo move-se lentamente e com rigor, filtrando erros que poderiam ser prejudiciais à saúde pública.Desde o início do século XX, três brasileiros - dois médicos e um químico - seguiram as regras científicas de desenvolvimento de fármacos, menos rigorosas que as atuais, e criaram medicamentos que foram usados por milhares de pessoas.Depois deles, nenhuma outra molécula biologicamente ativa original contra o câncer nascida em ambientes acadêmicos ou não acadêmicos conseguiu vencer todas as etapas de desenvolvimento e obter a aprovação para o uso amplo.Um dos propósitos deste livro é motivar a reflexão sobre a capacidade criativa de cientistas brasileiros e a importância da articulação entre especialistas de centros de pesquisas biomédicas, órgãos de governo e empresas, de modo que as possibilidades de novos tratamentos que se mostrarem consistentes não sejam perdidas.

Ano: 2019
Assunto: Medicina - Oncologia
Idioma: PORTUGUÊS
Nº de Páginas: 210