Publicações Científicas
2025
D'Amélio F, Vigerelli H, Araldi RP, Batista IFC, Pimenta DC, Kerkis I. Comprehensive RNA-Seq Analysis of Human
Osteoclast Function in Response to Bothrops moojeni Venom Fractions: Pathways of Bone Resorption and Cytoskeletal
Disruption. Toxins (Basel). 2025 Jul 19;17(7):358. doi: 10.3390/toxins17070358.
Toledo TM, Valerio HP, Melo AT, Gomes RN, Melo TC, Buri MV, Souza MM, Santos DM, Vigerelli H, Alvarez-Flores MP,
Palmisano G, Chudzinski-Tavassi AM. Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows
endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition. Cell Commun Signal. 2025
Jun 13;23(1):282. doi:
10.1186/s12964-025-02291-z.
Pereira PMC, Silva ACR, Asano KM, da Costa Neves A, Sciani JM, Pimenta DC, Vigerelli H. An Evaluation of the
Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action. Viruses. 2025 May
31;17(6):808. doi:
10.3390/v17060808.
Lichtenstein F, Souza D, Trufen C, Gonçalves V, Bernardes J, Baroni V, DeOcesano-Pereira C, Ormundo L, Souza F,
Ibañez O, Starobinas N, Lopes L, Andrade S, Chudzinski-Tavassi A. Digital Pathway Curation (DPC): a comparative
pipeline to assess the reproducibility, consensus and accuracy across Gemini, PubMed, and scientific reviewers in
biomedical research. May 2025. https://doi.org/10.48550/arXiv.2505.01259.
de Assis Silva GS, Bufalo MC, Medina de Souza M, DeOcesano-Pereira C, Chudzinski-Tavassi AM, Zambelli VO. Advanced
Glycation End-Products Sensitize Human Sensory-Like Neuron Cells to Capsaicin-Induced Calcium Influx. J Vis Exp. May
2;(219) (2025). https://doi.org/10.3390/cells11020247
Dias DA, Souza de Souza KF, Moslaves ISB, Buri MV, Basilio DCLS, Espinoça IT, Parisotto EB, Silva-Filho SE, Migliolo
L, Jaques JAO, Franco DG, Chudzinski-Tavassi AM, Rita PHS, da Silva DB, Carollo CA, Toffoli-Kadri MC, Paredes-Gamero
EJ. Identification of purinergic system components in the venom of Bothrops mattogrossensis and the inhibitory
effect of specioside extracted from Tabebuia aurea. Purinergic Signal. Apr;21(2):317-329 (2025). https://doi.org/10.1007/s11302-024-10032-z
Buri MV, Garavelli GY, Vigerelli H, de Souza MM, Maia Lobba AR, Ghidelli-Disse S, Chudzinski-Tavassi AM. cAmbly: A non-toxic cell-penetrating peptide derived from Amblyomin-X with targeted delivery to mitochondrial and cytoplasmic proteins. PLoS One. Mar 12;20(3):e0318119 (2025). https://doi.org/10.1371/journal.pone.0318119
D'Amélio F, Vigerelli H, Batista IFC, Araldi RP, Prieto-da-Silva ÁRB, Pimenta DC, Kerkis I. Selective Modulation of Osteoclast Function by Bothrops moojeni Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases. Toxins (Basel). 2025 Mar 15;17(3):141. doi: 10.3390/toxins17030141.
2024
Alvarez-Flores MP, Batista IFC, Villas Boas IM, Bufalo MC, de Souza JG, Oliveira DS, Bonfá G, Fernandes CM, Marques
Porto R, Lichtenstein F, Picolo G, Tambourgi DV, Chudzinski-Tavassi AM, Ibañez OCM, Teixeira C. Snake and arthropod
venoms: Search for inflammatory activity in human cells involved in joint diseases. Toxicon. 2024 Feb 1;238:107568.
doi: 10.1016/j.toxicon.2023.107568.
Cunegundes PS, de Souza JG , Oliveira DS , de Souza MM , AlvarezFlores MP , Gomes RN , de Melo TC and
Chudzinski-Tavassi AM. THP-1-Derived Dendritic Cells: A Rapid and Reproducible In Vitro Model for Phagocytosis
Assays Involving Tumor Cells. Adv Clin Toxicol. 2024; 9(4):000320.
doi: 10.23880/act-16000320.
Pohl PC, Villas-Boas IM, Pidde G, Tambourgi DV. Pararamosis, a Neglected Tropical Disease Induced by Premolis
semirufa Caterpillar Toxins: Investigating Their Effects on Synovial Cell Inflammation. Int J Mol Sci. 2024 Dec
6;25(23):13149. doi:
10.3390/ijms252313149.
2023
Dias de Oliveira FB, Antonioli E, Dias OFM, de Souza JG, Agarwal S, Chudzinski-Tavassi AM, Ferretti M. Comparative
Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by
Destabilization of Medial Meniscus. Int J Mol Sci. 2023 Oct 24;24(21):15543. doi: 10.3390/ijms242115543.
Fernández Vallone V, Borzone FR, Martinez LM, Giorello MB, Choi H, Dimase F, Feldman L, Bordenave RH, Chudzinski-Tavassi AM, Batagelj E, Chasseing NA. Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients. Front Oncol. 2023 Feb 20;13:1073793. doi: 10.3389/fonc.2023.1073793. eCollection 2023.
Hösch NG, Martins BB, Alcantara QA, Bufalo MC, Neto BS, Chudzinki-Tavassi AM, Santa-Cecilia FV, Cury Y, Zambelli VO. Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain. Eur J Pharmacol. 2023 Nov 15;959:176058. doi: 10.1016/j.ejphar.2023.176058.
Morais KLP, Ciccone L, Stura E, Alvarez-Flores MP, Mourier G, Vanden DM, Sciani JM, Iqbal A, Kalil SP, Pereira GJ, Marques-Porto R, Cunegundes P, Juliano L, Servent D, Chudzinski-Tavassi AM. Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front. Mol. Biosci. 2023 Jan 12;10:1072751. doi: 10.3389/fmolb.2023.1072751.
2022
Alvarez AM, Alvarez-Flores MP, DeOcesano-Pereira C, Goldfeder MB, Chudzinski-Tavassi AM, Moreira V, Teixeira C.
Losac and Lopap Recombinant Proteins from Lonomia obliqua Bristles Positively Modulate the Myoblast Proliferation
Process. Front Mol Biosci. 2022 Jun 29;9:904737. doi: 10.3389/fmolb.2022.904737
Alvarez-Flores MP, Gomes RN, Trevisan-Silva D, Oliveira DS, Batista IFC, Buri MV, Alvarez AM, DeOcesano-Pereira C,
de Souza MM, Chudzinski-Tavassi AM. Lonomia obliqua Envenoming and Innovative Research. Toxins. 2021, 13, 832. https://doi.org/10.3390/toxins1312083.
Andrade SA, Batalha-Carvalho JV, Curi R, Wen FH, Covas DT, Chudzinski-Tavassi AM, Moro AM. Equine Anti-SARS-CoV-2
Serum (ECIG) Binds to Mutated RBDs and N Proteins of Variants of Concern and Inhibits the Binding of RBDs to ACE-2
Receptor. Front Immunol. 2022 Jul 11;13:871874. doi: 10.3389/fimmu.2022.871874.
Apolinário AC, Salata GC, de Souza MM, Chorilli M, Lopes LB. Rethinking Breast Cancer Chemoprevention: Technological
Advantages and Enhanced Performance of a Nanoethosomal-Based Hydrogel for Topical Administration of Fenretinide.
AAPS PharmSciTech. 2022;23:104. https://doi.org/10.1208/s12249-022-02257-1.
Arruda GLM, Vigerelli H, Bufalo MC, Longato GB, Veloso RV, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC,
Sciani JM. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector
Effect. Biomed Res Int. 2021 Mar 4;2021:8855248. doi:
10.1155/2021/8855248.
Borrego A, Colombo F, de Souza JG, Jensen JR, Dassano A, Piazza R, Rodrigues Dos Santos BA, Ribeiro OG, De Franco M,
Cabrera WHK, Icimoto MY, Starobinas N, Magalhães G, Monteleone LF, Eto SF, DeOcesano-Pereira C, Goldfeder MB,
Pasqualoto KFM, Dragani TA, Ibañez OCM. Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome
Activation for IL-1β Production. Front Immunol. 2022 Jun 21;13:899569. doi: 10.3389/fimmu.2022.899569.
Botosso VF, Jorge SAC, Astray RM, de Sá Guimarães AM, Mathor MB, de Carneiro PDS, Durigon EL, Covas D, de Oliveira
DBL, das Neves Oliveira R, Maria DA, Eto SF, Gallina NMF, Pidde G, Squaiella-Baptistão CC, Silva DT, Villas-Boas IM,
Fernandes DC, Auada AVV, Banari AC, de Souza Filho AF, Bianconi C, de Agostini Utescher CL, Oliveira DCA, Mariano
DOC, Barbosa FF, Rondon G, Kapronezai J, da Silva JG, Goldfeder MB, Comone P, Junior REC, Pereira TTS, Wen FH,
Tambourgi DV, Chudzinski-Tavassi AM. Anti-SARS-CoV-2 equine F (Ab')2 immunoglobulin as a possible therapy for
COVID-19. Sci Rep. 2022 Mar 10;12(1):3890. doi:
10.1038/s41598-022-07793-1.
Bufalo MC, Almeida MES, Jensen JR, DeOcesano-Pereira C, Lichtenstein F, Picolo G, Chudzinski-Tavassi AM, Sampaio SC,
Cury Y, Zambelli VO. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of
Analgesic Compounds. Cells. 2022 Jan 12;11(2):247. doi: 10.3390/cells11020247.
de Melo TC, Trevisan-Silva D, Alvarez-Flores MP, Gomes RN, de Souza MM, Valerio HP, Oliveira DS, DeOcesano-Pereira
C, Botosso VF, Calil Jorge SA, Schattner M, Gomez RM, Chudzinski-Tavassi AM. Proteomic Analysis Identifies Molecular
Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial Cells. Int J Mol Sci. 2022 Sep
9;23(18):10452. doi: 10.3390/ijms231810452.
de Souza JG, Starobinas N, Ibañez OCM. Unknown/enigmatic functions of extracellular ASC. Immunology. 2021
Aug;163(4):377-388. doi: 10.1111/imm.13375.
DeOcesano-Pereira C, Machado RAC, Chudzinski-Tavassi AM, Sogayar MC. Emerging Roles and Potential Applications of
Non-Coding RNAs in Glioblastoma. Int J Mol Sci. 2020 Apr 9;21(7):2611. doi: 10.3390/ijms21072611.
Franca FOS, Medeiros RC, Zannin M, Lourenço DM, Chudzinski-Tavassi AM, Dourado FS, Torrez PPQ, Bertani R. Acidentes
por venenos e animais peçonhentos. TRATADO DE INFECTOLOGIA. 6ed. Rio de Janeiro: Ed. Atheneu, 2021, v. 2, p.
2471-2488.
Lazarini JG, Massarioli AP, Soares JC, Nani BD, Charo N, Oliveira DS, Camargo L, Alvarez-Flores MP, Batista IFC,
Chudzinski-Tavassi AM, Alencar SM, Franchin M, Rosalen PL. The phytoactive constituents of Eugenia selloi B.D. Jacks
(pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action. Food Chem (Oxf). 2022 Mar
7;4:100093. doi:
10.1016/j.fochms.2022.100093.
Linhares DDC, Faria F, Kodama RT, Amorim AMXP, Portaro FCV, Trevisan-Silva D, Ferraz KF, Chudzinski-Tavassi AM.
Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification,
and Characterization. Toxins (Basel). 2021 Dec 2;13(12):857. doi: 10.3390/toxins13120857
Lobba ARM, Alvarez-Flores MP, Fessel MR, Buri MV, Oliveira DS, Gomes RN, Cunegundes PS, DeOcesano-Pereira C, Cinel
C, Silva S, Chudzinski-Tavassi AM. Inhibition of Cancer Cell Migration by a Snake Venom Metalloproteinase from
Bothrops asper (MAP-1) in a 3D Collagen Matrix. Toxins (Basel). 2021 May 11;13(5):349. doi: 10.3390/toxins13050349.
Marcourakis T, Simas P, Rossi B, Fagundes B, Cerny S, Stedile A, Lima F, Trevisan-Silva D, Chudzinski-Tavassi AM,
Queiroz KC, Gomez MM. A comprehensive study of a rhizome extract of Cyperus rotundus L. for its chemical
characterization, antitumor and antidiabetic effects. J Ethnopharmacol. 2022 Jul 1;291:115044. doi: 10.1016/j.jep.2022.115044.
Munin E, Furtado J, Coelho D, Lima A, Peixoto F, Carvalho J, Olivares A, Picolo G, da Silva DB, Chudzinski-Tavassi
AM, Rodrigues D, Paiva J. Potential Antiviral Activity of Snake Venom Peptides Against SARS-CoV-2 In Vitro. Toxins.
2022 Aug 11;14(8):558. doi:
10.3390/toxins14080558.
Rodrigues BA, Chudzinski-Tavassi AM, Munin E, Furtado J, Santana DR, Silva RJ. Preliminary Assessment of the Use of
Chitohexaose as a Therapeutic Agent for Inflammatory Diseases. Toxins (Basel). 2021 Jun 9;13(6):387. doi: 10.3390/toxins13060387.
Sampaio SC, Mazzanti CM, Buri MV, Oliveira DS, Alvarez-Flores MP, Chudzinski-Tavassi AM. Structural and Functional
Characterization of a Snake Venom Protein, BPI-1, from Bothrops jararaca with Potential Therapeutic Applications. J
Biol Chem. 2022 Mar 11;297(10):101254. doi:
10.1016/j.jbc.2022.101254.
Vilela CA, Marangoni K, Nagaoka MR, Guisso C, DeOcesano-Pereira C, Chudzinski-Tavassi AM, Magalhães L. Evaluation of
Snake Venom's Potential in Treating Inflammatory Diseases: An In Vitro and In Vivo Approach. J Ethnopharmacol. 2022
Apr 8;281:114508. doi:
10.1016/j.jep.2021.114508.
2021
Alvarez AM, DeOcesano-Pereira C, Teixeira C, Moreira V. IL-1β and TNF-α Modulation of Proliferated and Committed
Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020 Sep
1;9(9):2005. doi: 10.3390/cells9092005.
Alvarez-Flores MP, Gomes RN, Trevisan-Silva D, Oliveira DS, Batista IFC, Buri MV, Alvarez AM, DeOcesano-Pereira C,
de Souza MM, Chudzinski-Tavassi AM. Lonomia obliqua Envenoming and Innovative Research. Toxins (Basel). 2021 Nov
23;13(12):832. doi: 10.3390/toxins13120832.
Aounallah H, Fessel MR, Goldfeder MB, Carvalho E, Bensaoud C, Chudzinski-Tavassi AM, Bouattour A, M'ghirbi Y, Faria
F. rDromaserpin: A Novel Anti-Hemostatic Serpin, from the Salivary Glands of the Hard Tick Hyalomma dromedarii.
Toxins (Basel). 2021 Dec 20;13(12):913. doi:
10.3390/toxins13120913
Arruda GLM, Vigerelli H, Bufalo MC, Longato GB, Veloso RV, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC,
Sciani JM. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector
Effect. Biomed Res Int. 2021 Mar 5;2021:8855248. doi:
10.1155/2021/8855248.
D'Amélio F, Vigerelli H, Prieto-da-Silva ÁRB, Osório Frare E, Batista IFC, Pimenta DC, Kerkis I. Bothrops moojeni
Venom and Its Components Strongly Affect Osteoclasts' Maturation and Protein Patterns. Toxins (Basel). 2021 Jun
30;13(7):459. doi: 10.3390/toxins13070459.
De Souza JG, Starobinas N, Ibañez OCM. Unknown/enigmatic functions of extracellular ASC. Immunology. 2021
Aug;163(4):377-388. doi: 10.1111/imm.13375.
Franca FOS, Medeiros RC, Zannin M, Lourenço DM, Chudzinski-Tavassi AM, Dourado FS, Torrez PPQ, Bertani R. Acidentes
por venenos e animais peçonhentos. TRATADO DE INFECTOLOGIA. 6ed. Rio de Janeiro: Ed. Atheneu, 2021, v. 2, p.
2471-2488.
Janovits PM, Leiguez E, Portas V, Teixeira C. A Metalloproteinase Induces an Inflammatory Response in Preadipocytes
with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A2. Biomolecules. 2021
Jun 22;11(7):921. doi: 10.3390/biom11070921.
Linhares DDC, Faria F, Kodama RT, Amorim AMXP, Portaro FCV, Trevisan-Silva D, Ferraz KF, Chudzinski-Tavassi AM.
Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification,
and Characterization. Toxins (Basel). 2021 Dec 2;13(12):857. doi: 10.3390/toxins13120857.
Oliveira DS, de Souza JG, Alvarez-Flores MP, Cunegundes PS, DeOcesano-Pereira C, Lobba AM, Gomes RN,
Chudzinski-Tavassi AM. Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in
THP-1-Derived Macrophage. Toxins. 2021 Jun 30;13(7):462. doi: 10.3390/toxins13070462.
Pidde G, Nishiyama MY, de Oliveira UC, Villas-Boas IM, Paes-Leme AF, Junqueira-de-Azevedo IL, Marques-Porto R,
Squaiella-Baptistão CC, Tambourgi DV. Integrative multiomics analysis of Premolis semirufa caterpillar venom in the
search for molecules leading to a joint disease. Sci Rep. 2021 Jan 21;11(1):1995. doi: 10.1038/s41598-020-79769-y.
Silva NC, Alvarez AM, DeOcesano-Pereira C, Fortes-Dias CL, Moreira V. Catalytically active phospholipase A2 myotoxin
from Crotalus durissus terrificus induces proliferation and differentiation of myoblasts dependent on prostaglandins
produced by both COX-1 and COX-2 pathways. Int J Biol Macromol. 2021 Jul 25;187:603-613. doi: 10.1016/j.ijbiomac.2021.07.121.
Villas-Boas IM, Pidde G, Lichtenstein F, Ching ATC, Junqueira-de-Azevedo ILM, DeOcesano-Pereira C, Madureira Trufen
CE, Chudzinski-Tavassi AM, Morais KLP, Tambourgi DV. Human chondrocyte activation by toxins from Premolis semirufa,
an Amazon rainforest moth caterpillar: identifying an osteoarthritis signature. Front Immunol. 2020 Sep 18;11:2191.
doi: 10.3389/fimmu.2020.02191.
2020
Alvarez AM, DeOcesano-Pereira C, Teixeira C, Moreira V. IL-1β and TNF-α Modulation of Proliferated and Committed
Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020 Sep
1;9(9):2005. doi: 10.3390/cells9092005.
DeOcesano-Pereira C, Machado RAC, Chudzinski-Tavassi AM, Sogayar MC. Emerging Roles and Potential Applications of
Non-Coding RNAs in Glioblastoma. Int J Mol Sci. 2020 Apr 9;21(7):2611. doi: 10.3390/ijms21072611.
Lichtenstein F, et al. Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a
horse melanoma model. Scientific Reports. 2020 Apr 14;10:6388. doi: 10.1038/s41598-020-63275-2.
Lobo YA, Bonazza C, Batista FP, Castro RA, Bonturi CR, Salu BR, de Cassia Sinigaglia R, Toma L, Vicente CM, Pidde G,
Tambourgi DV, Alvarez-Flores MP, Chudzinski-Tavassi AM, Oliva MLV. EcTI impairs survival and proliferation pathways
in triple-negative breast cancer by modulating cell-glycosaminoglycans and inflammatory cytokines. Cancer Lett. 2020
Oct 28;491:108-120. doi:
10.1016/j.canlet.2020.08.017.
Mambelli-Lisboa NC, Frare EO, da Costa-Neves A, Da Silva ÁRBP, Kerkis I. Murine osteoclastogenesis suppression using
conditioned media produced by melanoma or activated and non-activated Jurkat-E6 cells. Cell Biol Int.
2020;44(5):1184‐1192. doi: 10.1002/cbin.11317.
Schmidt MCB, Morais KLP, Almeida MES, Iqbal A, Goldfeder MB, Chudzinski-Tavassi AM. Amblyomin-X, a recombinant
Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. Cell Adh Migr. 2020
Dec;14(1):129-138. doi:
10.1080/19336918.2018.1516982.
Viana MN, Leiguez E, Gutiérrez JM, Rucavado A, Markus RP, Marçola M, Teixeira C, Fernandes CM. A Representative
Metalloprotease Induces PGE2 Synthesis in Fibroblast-Like Synoviocytes via the NF-κB/COX-2 Pathway With
Amplification by IL-1β and the EP4 Receptor. Sci Rep. 2020 Feb 24;10(1):3269. doi: 10.1038/s41598-020-59095-z.
Villas-Boas IM, Pidde G, Lichtenstein F, Ching ATC, Junqueira-de-Azevedo ILM, DeOcesano-Pereira C, Madureira Trufen
CE, Chudzinski-Tavassi AM, Morais KLP, Tambourgi DV. Human Chondrocyte Activation by Toxins From Premolis semirufa,
an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature. Front Immunol. 2020 Sep 18;11:2191.
doi: 10.3389/fimmu.2020.02191.
2019
Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of
rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter
MCT2 protein levels. J. Neurochemistry. 2019 Jan;148(1):80-96. doi: 10.1111/jnc.14617.
Batista IFC, Trufen CEM, Souza JG, Marques-Porto R, Portas VB, Jared C; Chudzinski-Tavassi AM. Centre of Excellence
in New Target Discovery: a Biobank establishment. Toxicon. 2019 Oct 5;168(1)
. doi: 10.1016/j.toxicon.2019.06.160.
Teixeira CFP, Fernandes CM, Leiguez E, Chudzinski-Tavassi AM. Inflammation Induced by Platelet-Activating Viperid
Snake Venoms: Perspectives on Thromboinflammation. Front Immunol. 2019 Sep 4;10:2082. doi: 10.3389/fimmu.2019.02082.
Borrego A, Cabrera WHK, Jensen JR, Correa M, Ribeiro OG, Starobinas N, De Franco M, Pettinicchio A, Dragani TA,
Ibañez OCM, Manenti G. Germline control of somatic Kras mutations in mouse lung tumors. Mol Carcinog. 2018
Jun;57(6):745-751. doi: 10.1002/mc.22796.
Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Biodistribution and Pharmacokinetics
of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Eur J Drug Metab Pharmacokinet. 2019
Feb;44(1):111-120. doi:
10.1007/s13318-018-0500-z.
Bufalo MC, Almeida ME, Franca IA, Zambelli VO, Sant'anna MBM, Kimura LK, Giardini AK, Cury Y, Sampaio SC. Advanced
glycation endproducts produced by in vitro glycation of type I collagen modulate the functional and secretory
behavior of dorsal root ganglion cells cultivated in two-dimensional system. Experimental Cell Research.
2019;382(2):111475. doi:
10.1016/j.yexcr.2019.06.020.
Chudzinski-Tavassi AM, Teixeira CFP, Tambourgi DV, Kerkis I, Batista IFB, Martinhez OCI, Cury Y. Centre of
Excellence in New Target Discovery (CENTD): new approach to inflammatory molecular targets and signaling pathways
identification. Toxicon. 2019. doi:
10.1016/j.toxicon.2019.06.161.
Cunegundes PS, De Souza JG, Oliveira DS, Chudzinski-Tavassi AM. A new differentiation method for THP-1-Derived
Dendritic cells. Toxicon. 2019 Oct 5;168(1)
. doi: 10.1016/j.toxicon.2019.06.164.
de Souza JG, Jensen JR, Starobinas N, Monteleone LF, Cabrera WH, Ibañez OC. Pycard gene Polymorphism and pristane
induced Arthritis in mice selected for acute inflammatory response. Osteoarthritis and Cartilage. 2019 Apr 1;27(1)
. doi: 10.1016/j.joca.2019.02.315.
de Carvalho LR, Borrego A, Jensen JR, Cabrera WHK, Santos AM, Ribeiro OG, Starobinas N, De Franco M, Dragani TA,
Manenti G, Ibañez OCM. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for
High or Low Inflammatory Response. J Immunol Res. 2019 Mar 31;2019:5298792. doi: 10.1155/2019/5298792.
Fernandes JG, Borrego A, Jensen JR, Cabrera WHK, Correa MA, Starobinas N, Ribeiro OG, Ibañez OM, De Franco M. miRNA
Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. J Immunol Res. 2018
Dec 16;2018:1928405. doi: 10.1155/2018/1928405.
Oliveira FBD, Antoniolli E, Souza JG, Dias OFM, Ferretti M. Mesenchymal stromal cells tracking and cytokines
kinetics following intra-articular and intravenous transplantation. Osteoarthritis and Cartilage. 2019 Apr 1;27(1)
. doi: 10.1016/j.joca.2019.02.315.
Oliveira FBD, Souza JG, Furiama O, Ferretti M, Antoniolli E. Imaging and functional assessment of medial meniscus
surgical destabilization animal model for osteoarthritis. Osteoarthritis and Cartilage. 2018 Apr 1;26(1)
. doi: 10.1016/j.joca.2018.02.889.
Pavon LF, Capper D, Sibov TT, de Toledo SRC, Thomale UW, de Souza JG, Cabral FR, Berra CM, Silva da Costa MD,
Mendonça Niçacio J, Dastoli PA, de Oliveira DM, Malheiros SMF, da Cruz EF, Malheiros JM, de Oliveira SM, Silva NS,
Petrilli AS, Cappellano AM, Brunialti MC, Salomão R, de Paiva Neto MA, Chudzinski-Tavassi AM, Cavalheiro S. New
therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type
molecule, Amblyomin-X. Sci Rep. 2019 Jul 10;9(1):9973. doi: 10.1038/s41598-019-45799-4.
Pavon LF, Sibov TT, de Souza AV, da Cruz EF, Malheiros SMF, Cabral FR, de Souza JG, Boufleur P, de Oliveira DM, de
Toledo SRC, Marti LC, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, Chudzinski-Tavassi AM, de Paiva Neto MA,
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A guerra contra o câncer no Brasil - Carlos Henrique Fioravant
Instituto Butantan - 15/10/2019
A obra "A Guerra contra o câncer no Brasil" da editora Atheneu mostra que os homens da ciência médica são tradutores de seu tempo, quando olham para as possibilidades de intervir no corpo individual e social para diminuir sofrimentos e encontrar os males que assolam a população.
SINOPSE
Antes era fácil-fácil demais- levar uma molécula nova para testes em hospitais. Agora, a engrenagem entre centros de pesquisa, hospitais, empresas e governo move-se lentamente e com rigor, filtrando erros que poderiam ser prejudiciais à saúde pública.Desde o início do século XX, três brasileiros - dois médicos e um químico - seguiram as regras científicas de desenvolvimento de fármacos, menos rigorosas que as atuais, e criaram medicamentos que foram usados por milhares de pessoas.Depois deles, nenhuma outra molécula biologicamente ativa original contra o câncer nascida em ambientes acadêmicos ou não acadêmicos conseguiu vencer todas as etapas de desenvolvimento e obter a aprovação para o uso amplo.Um dos propósitos deste livro é motivar a reflexão sobre a capacidade criativa de cientistas brasileiros e a importância da articulação entre especialistas de centros de pesquisas biomédicas, órgãos de governo e empresas, de modo que as possibilidades de novos tratamentos que se mostrarem consistentes não sejam perdidas.Ano: 2019
Assunto: Medicina - Oncologia
Idioma: PORTUGUÊS
Nº de Páginas: 210