Publicações Científicas



Botosso VF, Jorge SAC, Astray RM, de Sá Guimarães AM, Mathor MB, de Carneiro PDS, Durigon EL, Covas D, de Oliveira DBL, das Neves Oliveira R, Maria DA, Eto SF, Gallina NMF, Pidde G, Squaiella-Baptistão CC, Silva DT, Villas-Boas IM, Fernandes DC, Auada AVV, Banari AC, de Souza Filho AF, Bianconi C, de Agostini Utescher CL, Oliveira DCA, Mariano DOC, Barbosa FF, Rondon G, Kapronezai J, da Silva JG, Goldfeder MB, Comone P, Junior REC, Pereira TTS, Wen FH, Tambourgi DV, Chudzinski-Tavassi AM. Anti-SARS-CoV-2 equine F (Ab')2 immunoglobulin as a possible therapy for COVID-19. Sci Rep. 2022 Mar 10;12(1):3890. doi: 10.1038/s41598-022-07793-1.

Lazarini JG, Massarioli AP, Soares JC, Nani BD, Charo N, Oliveira DS, Camargo L, Alvarez-Flores MP, Batista IFCB, Chudzinski-Tavassi AM, Alencar SM, Franchin M, Rosalen PL. The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action. Food Chemistry: Molecular Sciences. 2022 Jul 30;4:100093.

Bufalo MC, Almeida MES, Jensen JR, DeOcesano-Pereira C, Lichtenstein F, Picolo G, Chudzinski-Tavassi AM, Sampaio SC, Cury Y, Zambelli VO. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds. Cells. 2022 Jan 12;11(2):247. doi: 10.3390/cells11020247.


Alvarez-Flores MP, Gomes RN, Trevisan-Silva D, Oliveira DS, Batista IFC, Buri MV, Alvarez AM, DeOcesano-Pereira C, de Souza MM, Chudzinski-Tavassi AM. Lonomia obliqua Envenoming and Innovative Research. Toxins (Basel). 2021 Nov 23;13(12):832. doi: 10.3390/toxins13120832. PMID: 34941670; PMCID: PMC8706654.

de Souza JG, Starobinas N, Ibañez OCM. Unknown/enigmatic functions of extracellular ASC. Immunology. 2021 Aug;163(4):377-388. DOI: 10.1111/imm.13375.

Alvarez AM, DeOcesano-Pereira C, Teixeira C, Moreira V. IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020 Sep 1;9(9):2005. DOI: 10.3390/cells9092005.

Silva NC, Alvarez AM, DeOcesano-Pereira C, Fortes-Dias CL, Moreira V. Catalytically active phospholipase A2 myotoxin from Crotalus durissus terrificus induces proliferation and differentiation of myoblasts dependent on prostaglandins produced by both COX-1 and COX-2 pathways. Int J Biol Macromol. 2021 Jul 25;187:603-613. DOI: 10.1016/j.ijbiomac.2021.07.121

Oliveira, D.S.; de Souza, J.G.; Alvarez-Flores, MP; Cunegundes, PS; DeOcesano-Pereira, C; Lobba, AM; Gomes, RN; Chudzinski-Tavassi, AM. Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage. Toxins. 2021 Jun 30; 13(7):462. DOI:10.3390/toxins13070462

Villas-Boas IM, Pidde G, Lichtenstein F, Ching ATC, Junqueira-de-Azevedo ILM, DeOcesano-Pereira C, Madureira Trufen CE, Chudzinski-Tavassi AM, Morais KLP, Tambourgi DV. Human chondrocyte activation by toxins from Premolis semirufa, an Amazon rainforest moth caterpillar: identifying an osteoarthritis signature. Front Immunol. 2020 Sep 18;11:2191. DOI: 10.3389/fimmu.2020.02191.

Pidde G, Nishiyama MY, de Oliveira UC, Villas-Boas IM, Paes-Leme AF, Junqueira-de-Azevedo IL, Marques-Porto R, Squaiella-Baptistão CC, Tambourgi DV. Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease. Sci Rep. 2021 Jan 21;11(1):1995. DOI: 10.1038/s41598-020-79769-y.

D'Amélio F, Vigerelli H, Prieto-da-Silva ÁRB, Osório Frare E, Batista IFC, Pimenta DC, Kerkis I. Bothrops moojeni Venom and Its Components Strongly Affect Osteoclasts' Maturation and Protein Patterns. Toxins (Basel). 2021 Jun 30;13(7):459. DOI: 10.3390/toxins13070459.

Arruda GLM, Vigerelli H, Bufalo MC, Longato GB, Veloso RV, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC, Sciani JM. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect. Biomed Res Int. 2021 Mar 5;2021:8855248. DOI: 10.1155/2021/8855248.

Janovits PM, Leiguez E, Portas V, Teixeira C. A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A2. Biomolecules. 2021 Jun 22;11(7):921. DOI: 10.3390/biom11070921.


Lichtenstein F, et al. Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model. Scientific Reports. 2020 Apr 14;10: 6388(2020). DOI: 10.1038/s41598-020-63275-2

Mambelli-Lisboa NC, Frare EO, da Costa-Neves A, Da Silva ÁRBP, Kerkis I. Murine osteoclastogenesis suppression using conditioned media produced by melanoma or activated and non-activated Jurkat-E6 cells. Cell Biol Int. 2020; 44(5):1184‐1192. DOI:10.1002/cbin.11317

DeOcesano-Pereira C, Machado RAC, Chudzinski-Tavassi AM, Sogayar MC. Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. Int J Mol Sci. 2020 Apr 9;21(7):2611. DOI: 10.3390/ijms21072611.

Viana MN, Leiguez E, Gutiérrez JM, Rucavado A, Markus RP, Marçola M, Teixeira C, Fernandes CM. A Representative Metalloprotease Induces PGE 2 Synthesis in Fibroblast-Like Synoviocytes via the NF-κB/COX-2 Pathway With Amplification by IL-1β and the EP4 Receptor. Sci Rep. 2020 Feb 24;10(1):3269. DOI: 10.1038/s41598-020-59095-z.


Bufalo, MC et al. Advanced glycation endproducts produced by in vitro glycation of type I collagen modulate the functional and secretory behavior of dorsal root ganglion cells cultivated in two-dimensional system. Experimental Cell Research. 2019; 382(2):111475. DOI: 10.1016/j.yexcr.2019.06.020.

Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):111-120. DOI: 10.1007/s13318-018-0500-z

Chudzinski-Tavassi AM, Teixeira CFP, Tambourgi DV, Kerkis I, Batista IFB, Martinhez OCI, Cury Y. Centre of Excellence in New Target Discovery (CENTD): new approach to inflammatory molecular targets and signaling pathways identification. Toxicon. 2019. DOI: 10.1016/j.toxicon.2019.06.161

Batista IFC, Trufen CEM, Souza JG, Marques-Porto R, Portas VB, Jared C; Chudzinski-Tavassi AM. Centre of Excellence in New Target Discovery: a Biobank establishment. Toxicon. 2019 Oct 5; 168(1):S1-S42. DOI: 10.1016/j.toxicon.2019.06.160 Teixeira CFP, Fernandes CM, Leiguez E, Chudzinski-Tavassi AM. Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation. Front Immunol. 2019 Sep 4;10:2082. DOI: 10.3389/fimmu.2019.02082. eCollection 2019.

Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. J. Neurochemistry. 2019 Jan;148(1):80-96. DOI: 10.1111/jnc.14617.

Pavon LF, Capper D, Sibov TT, de Toledo SRC, Thomale UW, de Souza JG, Cabral FR, Berra CM, Silva da Costa MD, Mendonça Niçacio J, Dastoli PA, de Oliveira DM, Malheiros SMF, da Cruz EF, Malheiros JM, de Oliveira SM, Silva NS, Petrilli AS, Cappellano AM, Brunialti MC, Salomão R, de Paiva Neto MA, Chudzinski-Tavassi AM, Cavalheiro S. New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X. Sci Rep. 2019 Jul 10;9(1):9973. DOI: 10.1038/s41598-019-45799-4

Cunegundes PS, De Souza JG, Oliveira DS, Chudzinski-Tavassi AM. A new differentiation method for THP-1-Derived Dendritic cells. Toxicon. 2019 Oct 5; 168(1):S41-S42. DOI:10.1016/j.toxicon.2019.06.164 de Souza JG, Jensen JR, Starobinas N, Monteleone LF, Cabrera WH, Ibañez OC. Pycard gene Polymorphism and pristane induced Arthritis in mice selected for acute inflammatory response. Osteoarthritis and Cartilage. 2019 Apr 1; 27(1):S381. DOI: 10.1016/j.joca.2019.02.315.

Oliveira FBD, Antoniolli E, Souza JG, Dias OFM, Ferretti M. Mesenchymal stromal cells tracking and cytokines kinetics following intra-articular and intravenous transplantation. Osteoarthritis and Cartilage. 2019 Apr 1; 27(1):S203-S204. DOI: 10.1016/j.joca.2019.02.315.

Oliveira FBD, Souza JG, Furiama O, Ferretti M, Antoniolli E. Imaging and functional assessment of medial meniscus surgical destabilization animal model for osteoarthritis. Osteoarthritis and Cartilage. 2018 Apr 1; 26(1): S471-S472. DOI: 10.1016/j.joca.2018.02.889.

Sibov TT, Pavon LF, Cabral FR, Cunha IF, De Oliveira DM, De Souza JG, Marti LC, Da Cruz EF, Malheiros JM, Paiva FF, Tannús A, De Oliveira SM, Da Costa MDS, Dastoli PA, Mendonça JN, De Toledo SRC, Malheiros SMF, De Paiva Neto MA, Rego NBB, Moron AF, Cavalheiro S. Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke. Cell Transplant. Sep-Oct 2019;28(9-10):1306-1320. DOI: 10.1177/0963689719854342

Pavon LF, Sibov TT, de Souza AV, da Cruz EF, Malheiros SMF, Cabral FR, de Souza JG, Boufleur P, de Oliveira DM, de Toledo SRC, Marti LC, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, Chudzinski-Tavassi AM, de Paiva Neto MA, Cavalheiro S. Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo. Stem Cell Res Ther. 2018 Nov 9;9(1):310. DOI: 10.1186/s13287-018-1049-0.

de Carvalho LR, Borrego A, Jensen JR, Cabrera WHK, Santos AM, Ribeiro OG, Starobinas N, De Franco M, Dragani TA, Manenti G, Ibañez OCM. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response. J Immunol Res. 2019 Mar 31;2019:5298792. DOI: 10.1155/2019/5298792.

Rossato C, Albuquerque LL, Katz ISS, Borrego A, Cabrera WHK, Spadafora-Ferreira M, Ribeiro OG, Starobinas N, Ibañez OM, De Franco M, Jensen JR. Early Peritoneal CC Chemokine Production Correlates with Divergent Inflammatory Phenotypes and Susceptibility to Experimental Arthritis in Mice. J Immunol Res. 2019 Feb 26;2019:2641098. DOI: 10.1155/2019/2641098.

Borrego A, Cabrera WHK, Jensen JR, Correa M, Ribeiro OG, Starobinas N, De Franco M, Pettinicchio A, Dragani TA, Ibañez OCM, Manenti G. Germline control of somatic Kras mutations in mouse lung tumors. Mol Carcinog. 2018 Jun;57(6):745-751. DOI: 10.1002/mc.22796.

Fernandes JG, Borrego A, Jensen JR, Cabrera WHK, Correa MA, Starobinas N, Ribeiro OG, Ibañez OM, De Franco M. miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. J Immunol Res. 2018 Dec 16;2018:1928405. DOI: 10.1155/2018/1928405.


Villas-Boas IM, Bonfá G, Tambourgi D V. Venomous caterpillars: From inoculation apparatus to venom composition and envenomation. Toxicon. 2018 Oct;153:39-52. DOI: 10.1016/j.toxicon.2018.08.007.

Mambelli-Lisboa NC, Mozer Sciani J, Rossan Brandão Prieto da Silva A, Kerkis I. Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells. Molecules. 2018 Apr 20;23(4):968. DOI: 10.3390/molecules23040968.

Bufalo MC, Almeida MES, Zambelli VO, Sampaio SC, Sant’Anna MB, Kimura LF, Giardini AC, Cury Y. Glycated collagen induces pro-inflammatory factors activation on rat dorsal root ganglion (DRG) primary culture. Third International Symposium on Inflammatory Diseases – INFLAMMA III; June 21th to 23th, 2017; Ribeirão Preto, SP. Exp Cell Res. 2019. DOI: 10.1016/j.yexcr.2019.06.020.

Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintainance of monocarboxylate transporter MCT2 protein levels. J. Neurochemistry. 2019 Jan;148(1):80-96. DOI: 10.1111/jnc.14617. Epub 2018 Dec 3.

Chudzinski-Tavassi AM, Faria F, Alvarez-Flores MP. Anticoagulants from Hematophagous. In: Božič-Mijovski M, editor. Anticoagulant Drugs. London: Intochopen; 2018 Nov 5. Chapter 3, p. 39-61. DOI: 10.5772/intechopen.78025

Schmidt MCB, Morais KLP, Almeida MES, Iqbal A, Goldfeder MB, Chudzinski-Tavassi AM. Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. Cell Adh Migr. 2018 Sep 25;14(1)129-138. DOI: 10.1080/19336918.2018.1516982.

Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):111-120. DOI: 10.1007/s13318-018-0500-z.

Chudzinski-Tavassi AM, Morais KLP, de Souza JG, Chammas R. Role of Immune System in Kidney Cancer. In: Kommu SS, Gill I, editors. Evolving Trends in Kidney Cancer. London: Intochopen; 2018 Nov 5. DOI: 10.5772/intechopen.77379.

Maria DA, Will SEAL, Bosch RV, Souza JG, Sciani JM, Goldfeder MB, Rondon GG, Chudzinski-Tavassi AM. Preclinical evaluation of Amblyomin-X, a Kunitz-type protease inhibitor with antitumor activity. Toxicol Rep. 2018 Dec 1;6:51-63. DOI: 10.1016/j.toxrep.2018.11.014.


Iqbal A, Goldfeder MB, Marques-Porto R, Asif H, Souza JG, Faria F, Chudzinski-Tavassi AM. Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin. Sci Rep. 2017 May 3;7(1):1431. DOI: 10.1038/s41598-017-01486-w.

Kerkis I, de Brandão Prieto da Silva AR, Pompeia C, Tytgat J, de Sá Junior PL. Toxin bioportides: exploring toxin biological activity and multifunctionality. Cell Mol Life Sci. 2017 Feb;74(4):647-661. doi: 10.1007/s00018-016-2343-6.


Branco VG, Iqbal A, Alvarez-Flores MP, Sciani JM, de Andrade SA, Iwai LK, Serrano SM, Chudzinski-Tavassi AM. Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo. Biochim Biophys Acta. 2016 Oct;1864(10):1428-35. DOI: 10.1016/j.bbapap.2016.07.011.

de Souza JG, Morais KL, Anglés-Cano E, Boufleur P, de Mello ES, Maria DA, Origassa CS, de Campos Zampolli H, Câmara NO, Berra CM, Bosch RV, Chudzinski-Tavassi AM. Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model. Oncotarget. 2016 Aug 23. DOI: 10.18632/oncotarget.11555.


A guerra contra o câncer no Brasil - Carlos Henrique Fioravant

Instituto Butantan - 15/10/2019

A guerra contra o câncer no Brasil - Carlos Henrique Fioravant

A obra "A Guerra contra o câncer no Brasil" da editora Atheneu mostra que os homens da ciência médica são tradutores de seu tempo, quando olham para as possibilidades de intervir no corpo individual e social para diminuir sofrimentos e encontrar os males que assolam a população.


Antes era fácil-fácil demais- levar uma molécula nova para testes em hospitais. Agora, a engrenagem entre centros de pesquisa, hospitais, empresas e governo move-se lentamente e com rigor, filtrando erros que poderiam ser prejudiciais à saúde pública.Desde o início do século XX, três brasileiros - dois médicos e um químico - seguiram as regras científicas de desenvolvimento de fármacos, menos rigorosas que as atuais, e criaram medicamentos que foram usados por milhares de pessoas.Depois deles, nenhuma outra molécula biologicamente ativa original contra o câncer nascida em ambientes acadêmicos ou não acadêmicos conseguiu vencer todas as etapas de desenvolvimento e obter a aprovação para o uso amplo.Um dos propósitos deste livro é motivar a reflexão sobre a capacidade criativa de cientistas brasileiros e a importância da articulação entre especialistas de centros de pesquisas biomédicas, órgãos de governo e empresas, de modo que as possibilidades de novos tratamentos que se mostrarem consistentes não sejam perdidas.

Ano: 2019
Assunto: Medicina - Oncologia
Nº de Páginas: 210