Publicações Científicas

2025

De Lima CL, Pohl PC, Villas-Boas IM, Pidde G, Tambourgi DV. Investigating the impact of Premolis semirufa caterpillar bristle toxins on human chondrocyte activation and inflammation. PLoS Negl Trop Dis. 2025 Feb 10;19(2):e0012816. doi: 10.1371/journal.pntd.0012816.

Buri MV, Garavelli GY, Vigerelli H, Souza MM, Lobba ARM, Ghidelli-Disse S, Chudzinski-Tavassi AM. cAmbly: A non-toxic cell-penetrating peptide derived from Amblyomin-X with targeted delivery to mitochondrial and cytoplasmic proteins. PLoS One. 2025 Mar 12;20(3):e0318119. doi: 10.1371/journal.pone.0318119.

D'Amélio F, Vigerelli H, Batista IFC, Araldi RP, Prieto-da-Silva ÁRB, Pimenta DC, Kerkis I. Selective Modulation of Osteoclast Function by Bothrops moojeni Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases. Toxins (Basel). 2025 Mar 15;17(3):141. doi: 10.3390/toxins17030141.

2024

Alvarez-Flores MP, Batista IFC, Villas Boas IM, Bufalo MC, de Souza JG, Oliveira DS, Bonfá G, Fernandes CM, Marques Porto R, Lichtenstein F, Picolo G, Tambourgi DV, Chudzinski-Tavassi AM, Ibañez OCM, Teixeira C. Snake and arthropod venoms: Search for inflammatory activity in human cells involved in joint diseases. Toxicon. 2024 Feb 1;238:107568. doi: 10.1016/j.toxicon.2023.107568.

Cunegundes PS, de Souza JG , Oliveira DS , de Souza MM , AlvarezFlores MP , Gomes RN , de Melo TC and Chudzinski-Tavassi AM. THP-1-Derived Dendritic Cells: A Rapid and Reproducible In Vitro Model for Phagocytosis Assays Involving Tumor Cells. Adv Clin Toxicol. 2024; 9(4):000320. doi: 10.23880/act-16000320.

Pohl PC, Villas-Boas IM, Pidde G, Tambourgi DV. Pararamosis, a Neglected Tropical Disease Induced by Premolis semirufa Caterpillar Toxins: Investigating Their Effects on Synovial Cell Inflammation. Int J Mol Sci. 2024 Dec 6;25(23):13149. doi: 10.3390/ijms252313149.

2023

Dias de Oliveira FB, Antonioli E, Dias OFM, de Souza JG, Agarwal S, Chudzinski-Tavassi AM, Ferretti M. Comparative Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by Destabilization of Medial Meniscus. Int J Mol Sci. 2023 Oct 24;24(21):15543. doi: 10.3390/ijms242115543.

Fernández Vallone V, Borzone FR, Martinez LM, Giorello MB, Choi H, Dimase F, Feldman L, Bordenave RH, Chudzinski-Tavassi AM, Batagelj E, Chasseing NA. Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients. Front Oncol. 2023 Feb 20;13:1073793. doi: 10.3389/fonc.2023.1073793. eCollection 2023.

Hösch NG, Martins BB, Alcantara QA, Bufalo MC, Neto BS, Chudzinki-Tavassi AM, Santa-Cecilia FV, Cury Y, Zambelli VO. Wnt signaling is involved in crotalphine-induced analgesia in a rat model of neuropathic pain. Eur J Pharmacol. 2023 Nov 15;959:176058. doi: 10.1016/j.ejphar.2023.176058.

Morais KLP, Ciccone L, Stura E, Alvarez-Flores MP, Mourier G, Vanden DM, Sciani JM, Iqbal A, Kalil SP, Pereira GJ, Marques-Porto R, Cunegundes P, Juliano L, Servent D, Chudzinski-Tavassi AM. Structural and functional properties of the Kunitz-type and C-terminal domains of Amblyomin-X supporting its antitumor activity. Front. Mol. Biosci. 2023 Jan 12;10:1072751. doi: 10.3389/fmolb.2023.1072751.

2022

Alvarez AM, Alvarez-Flores MP, DeOcesano-Pereira C, Goldfeder MB, Chudzinski-Tavassi AM, Moreira V, Teixeira C. Losac and Lopap Recombinant Proteins from Lonomia obliqua Bristles Positively Modulate the Myoblast Proliferation Process. Front Mol Biosci. 2022 Jun 29;9:904737. doi: 10.3389/fmolb.2022.904737

Alvarez-Flores MP, Gomes RN, Trevisan-Silva D, Oliveira DS, Batista IFC, Buri MV, Alvarez AM, DeOcesano-Pereira C, de Souza MM, Chudzinski-Tavassi AM. Lonomia obliqua Envenoming and Innovative Research. Toxins. 2021, 13, 832. https://doi.org/10.3390/toxins1312083.

Andrade SA, Batalha-Carvalho JV, Curi R, Wen FH, Covas DT, Chudzinski-Tavassi AM, Moro AM. Equine Anti-SARS-CoV-2 Serum (ECIG) Binds to Mutated RBDs and N Proteins of Variants of Concern and Inhibits the Binding of RBDs to ACE-2 Receptor. Front Immunol. 2022 Jul 11;13:871874. doi: 10.3389/fimmu.2022.871874.

Apolinário AC, Salata GC, de Souza MM, Chorilli M, Lopes LB. Rethinking Breast Cancer Chemoprevention: Technological Advantages and Enhanced Performance of a Nanoethosomal-Based Hydrogel for Topical Administration of Fenretinide. AAPS PharmSciTech. 2022;23:104. https://doi.org/10.1208/s12249-022-02257-1.

Arruda GLM, Vigerelli H, Bufalo MC, Longato GB, Veloso RV, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC, Sciani JM. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect. Biomed Res Int. 2021 Mar 4;2021:8855248. doi: 10.1155/2021/8855248.

Borrego A, Colombo F, de Souza JG, Jensen JR, Dassano A, Piazza R, Rodrigues Dos Santos BA, Ribeiro OG, De Franco M, Cabrera WHK, Icimoto MY, Starobinas N, Magalhães G, Monteleone LF, Eto SF, DeOcesano-Pereira C, Goldfeder MB, Pasqualoto KFM, Dragani TA, Ibañez OCM. Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production. Front Immunol. 2022 Jun 21;13:899569. doi: 10.3389/fimmu.2022.899569.

Botosso VF, Jorge SAC, Astray RM, de Sá Guimarães AM, Mathor MB, de Carneiro PDS, Durigon EL, Covas D, de Oliveira DBL, das Neves Oliveira R, Maria DA, Eto SF, Gallina NMF, Pidde G, Squaiella-Baptistão CC, Silva DT, Villas-Boas IM, Fernandes DC, Auada AVV, Banari AC, de Souza Filho AF, Bianconi C, de Agostini Utescher CL, Oliveira DCA, Mariano DOC, Barbosa FF, Rondon G, Kapronezai J, da Silva JG, Goldfeder MB, Comone P, Junior REC, Pereira TTS, Wen FH, Tambourgi DV, Chudzinski-Tavassi AM. Anti-SARS-CoV-2 equine F (Ab')2 immunoglobulin as a possible therapy for COVID-19. Sci Rep. 2022 Mar 10;12(1):3890. doi: 10.1038/s41598-022-07793-1.

Bufalo MC, Almeida MES, Jensen JR, DeOcesano-Pereira C, Lichtenstein F, Picolo G, Chudzinski-Tavassi AM, Sampaio SC, Cury Y, Zambelli VO. Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds. Cells. 2022 Jan 12;11(2):247. doi: 10.3390/cells11020247.

de Melo TC, Trevisan-Silva D, Alvarez-Flores MP, Gomes RN, de Souza MM, Valerio HP, Oliveira DS, DeOcesano-Pereira C, Botosso VF, Calil Jorge SA, Schattner M, Gomez RM, Chudzinski-Tavassi AM. Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial Cells. Int J Mol Sci. 2022 Sep 9;23(18):10452. doi: 10.3390/ijms231810452.

de Souza JG, Starobinas N, Ibañez OCM. Unknown/enigmatic functions of extracellular ASC. Immunology. 2021 Aug;163(4):377-388. doi: 10.1111/imm.13375.

DeOcesano-Pereira C, Machado RAC, Chudzinski-Tavassi AM, Sogayar MC. Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. Int J Mol Sci. 2020 Apr 9;21(7):2611. doi: 10.3390/ijms21072611.

Franca FOS, Medeiros RC, Zannin M, Lourenço DM, Chudzinski-Tavassi AM, Dourado FS, Torrez PPQ, Bertani R. Acidentes por venenos e animais peçonhentos. TRATADO DE INFECTOLOGIA. 6ed. Rio de Janeiro: Ed. Atheneu, 2021, v. 2, p. 2471-2488.

Lazarini JG, Massarioli AP, Soares JC, Nani BD, Charo N, Oliveira DS, Camargo L, Alvarez-Flores MP, Batista IFC, Chudzinski-Tavassi AM, Alencar SM, Franchin M, Rosalen PL. The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action. Food Chem (Oxf). 2022 Mar 7;4:100093. doi: 10.1016/j.fochms.2022.100093.

Linhares DDC, Faria F, Kodama RT, Amorim AMXP, Portaro FCV, Trevisan-Silva D, Ferraz KF, Chudzinski-Tavassi AM. Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification, and Characterization. Toxins (Basel). 2021 Dec 2;13(12):857. doi: 10.3390/toxins13120857

Lobba ARM, Alvarez-Flores MP, Fessel MR, Buri MV, Oliveira DS, Gomes RN, Cunegundes PS, DeOcesano-Pereira C, Cinel C, Silva S, Chudzinski-Tavassi AM. Inhibition of Cancer Cell Migration by a Snake Venom Metalloproteinase from Bothrops asper (MAP-1) in a 3D Collagen Matrix. Toxins (Basel). 2021 May 11;13(5):349. doi: 10.3390/toxins13050349.

Marcourakis T, Simas P, Rossi B, Fagundes B, Cerny S, Stedile A, Lima F, Trevisan-Silva D, Chudzinski-Tavassi AM, Queiroz KC, Gomez MM. A comprehensive study of a rhizome extract of Cyperus rotundus L. for its chemical characterization, antitumor and antidiabetic effects. J Ethnopharmacol. 2022 Jul 1;291:115044. doi: 10.1016/j.jep.2022.115044.

Munin E, Furtado J, Coelho D, Lima A, Peixoto F, Carvalho J, Olivares A, Picolo G, da Silva DB, Chudzinski-Tavassi AM, Rodrigues D, Paiva J. Potential Antiviral Activity of Snake Venom Peptides Against SARS-CoV-2 In Vitro. Toxins. 2022 Aug 11;14(8):558. doi: 10.3390/toxins14080558.

Rodrigues BA, Chudzinski-Tavassi AM, Munin E, Furtado J, Santana DR, Silva RJ. Preliminary Assessment of the Use of Chitohexaose as a Therapeutic Agent for Inflammatory Diseases. Toxins (Basel). 2021 Jun 9;13(6):387. doi: 10.3390/toxins13060387.

Sampaio SC, Mazzanti CM, Buri MV, Oliveira DS, Alvarez-Flores MP, Chudzinski-Tavassi AM. Structural and Functional Characterization of a Snake Venom Protein, BPI-1, from Bothrops jararaca with Potential Therapeutic Applications. J Biol Chem. 2022 Mar 11;297(10):101254. doi: 10.1016/j.jbc.2022.101254.

Vilela CA, Marangoni K, Nagaoka MR, Guisso C, DeOcesano-Pereira C, Chudzinski-Tavassi AM, Magalhães L. Evaluation of Snake Venom's Potential in Treating Inflammatory Diseases: An In Vitro and In Vivo Approach. J Ethnopharmacol. 2022 Apr 8;281:114508. doi: 10.1016/j.jep.2021.114508.

2021

Alvarez AM, DeOcesano-Pereira C, Teixeira C, Moreira V. IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020 Sep 1;9(9):2005. doi: 10.3390/cells9092005.

Alvarez-Flores MP, Gomes RN, Trevisan-Silva D, Oliveira DS, Batista IFC, Buri MV, Alvarez AM, DeOcesano-Pereira C, de Souza MM, Chudzinski-Tavassi AM. Lonomia obliqua Envenoming and Innovative Research. Toxins (Basel). 2021 Nov 23;13(12):832. doi: 10.3390/toxins13120832.

Aounallah H, Fessel MR, Goldfeder MB, Carvalho E, Bensaoud C, Chudzinski-Tavassi AM, Bouattour A, M'ghirbi Y, Faria F. rDromaserpin: A Novel Anti-Hemostatic Serpin, from the Salivary Glands of the Hard Tick Hyalomma dromedarii. Toxins (Basel). 2021 Dec 20;13(12):913. doi: 10.3390/toxins13120913

Arruda GLM, Vigerelli H, Bufalo MC, Longato GB, Veloso RV, Zambelli VO, Picolo G, Cury Y, Morandini AC, Marques AC, Sciani JM. Box Jellyfish (Cnidaria, Cubozoa) Extract Increases Neuron's Connection: A Possible Neuroprotector Effect. Biomed Res Int. 2021 Mar 5;2021:8855248. doi: 10.1155/2021/8855248.

D'Amélio F, Vigerelli H, Prieto-da-Silva ÁRB, Osório Frare E, Batista IFC, Pimenta DC, Kerkis I. Bothrops moojeni Venom and Its Components Strongly Affect Osteoclasts' Maturation and Protein Patterns. Toxins (Basel). 2021 Jun 30;13(7):459. doi: 10.3390/toxins13070459.

De Souza JG, Starobinas N, Ibañez OCM. Unknown/enigmatic functions of extracellular ASC. Immunology. 2021 Aug;163(4):377-388. doi: 10.1111/imm.13375.

Franca FOS, Medeiros RC, Zannin M, Lourenço DM, Chudzinski-Tavassi AM, Dourado FS, Torrez PPQ, Bertani R. Acidentes por venenos e animais peçonhentos. TRATADO DE INFECTOLOGIA. 6ed. Rio de Janeiro: Ed. Atheneu, 2021, v. 2, p. 2471-2488.

Janovits PM, Leiguez E, Portas V, Teixeira C. A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A2. Biomolecules. 2021 Jun 22;11(7):921. doi: 10.3390/biom11070921.

Linhares DDC, Faria F, Kodama RT, Amorim AMXP, Portaro FCV, Trevisan-Silva D, Ferraz KF, Chudzinski-Tavassi AM. Novel Cysteine Protease Inhibitor Derived from the Haementeria vizottoi Leech: Recombinant Expression, Purification, and Characterization. Toxins (Basel). 2021 Dec 2;13(12):857. doi: 10.3390/toxins13120857.

Oliveira DS, de Souza JG, Alvarez-Flores MP, Cunegundes PS, DeOcesano-Pereira C, Lobba AM, Gomes RN, Chudzinski-Tavassi AM. Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage. Toxins. 2021 Jun 30;13(7):462. doi: 10.3390/toxins13070462.

Pidde G, Nishiyama MY, de Oliveira UC, Villas-Boas IM, Paes-Leme AF, Junqueira-de-Azevedo IL, Marques-Porto R, Squaiella-Baptistão CC, Tambourgi DV. Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease. Sci Rep. 2021 Jan 21;11(1):1995. doi: 10.1038/s41598-020-79769-y.

Silva NC, Alvarez AM, DeOcesano-Pereira C, Fortes-Dias CL, Moreira V. Catalytically active phospholipase A2 myotoxin from Crotalus durissus terrificus induces proliferation and differentiation of myoblasts dependent on prostaglandins produced by both COX-1 and COX-2 pathways. Int J Biol Macromol. 2021 Jul 25;187:603-613. doi: 10.1016/j.ijbiomac.2021.07.121.

Villas-Boas IM, Pidde G, Lichtenstein F, Ching ATC, Junqueira-de-Azevedo ILM, DeOcesano-Pereira C, Madureira Trufen CE, Chudzinski-Tavassi AM, Morais KLP, Tambourgi DV. Human chondrocyte activation by toxins from Premolis semirufa, an Amazon rainforest moth caterpillar: identifying an osteoarthritis signature. Front Immunol. 2020 Sep 18;11:2191. doi: 10.3389/fimmu.2020.02191.

2020

Alvarez AM, DeOcesano-Pereira C, Teixeira C, Moreira V. IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved. Cells. 2020 Sep 1;9(9):2005. doi: 10.3390/cells9092005.

DeOcesano-Pereira C, Machado RAC, Chudzinski-Tavassi AM, Sogayar MC. Emerging Roles and Potential Applications of Non-Coding RNAs in Glioblastoma. Int J Mol Sci. 2020 Apr 9;21(7):2611. doi: 10.3390/ijms21072611.

Lichtenstein F, et al. Modulation of stress and immune response by Amblyomin-X results in tumor cell death in a horse melanoma model. Scientific Reports. 2020 Apr 14;10:6388. doi: 10.1038/s41598-020-63275-2.

Lobo YA, Bonazza C, Batista FP, Castro RA, Bonturi CR, Salu BR, de Cassia Sinigaglia R, Toma L, Vicente CM, Pidde G, Tambourgi DV, Alvarez-Flores MP, Chudzinski-Tavassi AM, Oliva MLV. EcTI impairs survival and proliferation pathways in triple-negative breast cancer by modulating cell-glycosaminoglycans and inflammatory cytokines. Cancer Lett. 2020 Oct 28;491:108-120. doi: 10.1016/j.canlet.2020.08.017.

Mambelli-Lisboa NC, Frare EO, da Costa-Neves A, Da Silva ÁRBP, Kerkis I. Murine osteoclastogenesis suppression using conditioned media produced by melanoma or activated and non-activated Jurkat-E6 cells. Cell Biol Int. 2020;44(5):1184‐1192. doi: 10.1002/cbin.11317.

Schmidt MCB, Morais KLP, Almeida MES, Iqbal A, Goldfeder MB, Chudzinski-Tavassi AM. Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. Cell Adh Migr. 2020 Dec;14(1):129-138. doi: 10.1080/19336918.2018.1516982.

Viana MN, Leiguez E, Gutiérrez JM, Rucavado A, Markus RP, Marçola M, Teixeira C, Fernandes CM. A Representative Metalloprotease Induces PGE2 Synthesis in Fibroblast-Like Synoviocytes via the NF-κB/COX-2 Pathway With Amplification by IL-1β and the EP4 Receptor. Sci Rep. 2020 Feb 24;10(1):3269. doi: 10.1038/s41598-020-59095-z.

Villas-Boas IM, Pidde G, Lichtenstein F, Ching ATC, Junqueira-de-Azevedo ILM, DeOcesano-Pereira C, Madureira Trufen CE, Chudzinski-Tavassi AM, Morais KLP, Tambourgi DV. Human Chondrocyte Activation by Toxins From Premolis semirufa, an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature. Front Immunol. 2020 Sep 18;11:2191. doi: 10.3389/fimmu.2020.02191.

2019

Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. J. Neurochemistry. 2019 Jan;148(1):80-96. doi: 10.1111/jnc.14617.

Batista IFC, Trufen CEM, Souza JG, Marques-Porto R, Portas VB, Jared C; Chudzinski-Tavassi AM. Centre of Excellence in New Target Discovery: a Biobank establishment. Toxicon. 2019 Oct 5;168(1) . doi: 10.1016/j.toxicon.2019.06.160.

Teixeira CFP, Fernandes CM, Leiguez E, Chudzinski-Tavassi AM. Inflammation Induced by Platelet-Activating Viperid Snake Venoms: Perspectives on Thromboinflammation. Front Immunol. 2019 Sep 4;10:2082. doi: 10.3389/fimmu.2019.02082.

Borrego A, Cabrera WHK, Jensen JR, Correa M, Ribeiro OG, Starobinas N, De Franco M, Pettinicchio A, Dragani TA, Ibañez OCM, Manenti G. Germline control of somatic Kras mutations in mouse lung tumors. Mol Carcinog. 2018 Jun;57(6):745-751. doi: 10.1002/mc.22796.

Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):111-120. doi: 10.1007/s13318-018-0500-z.

Bufalo MC, Almeida ME, Franca IA, Zambelli VO, Sant'anna MBM, Kimura LK, Giardini AK, Cury Y, Sampaio SC. Advanced glycation endproducts produced by in vitro glycation of type I collagen modulate the functional and secretory behavior of dorsal root ganglion cells cultivated in two-dimensional system. Experimental Cell Research. 2019;382(2):111475. doi: 10.1016/j.yexcr.2019.06.020.

Chudzinski-Tavassi AM, Teixeira CFP, Tambourgi DV, Kerkis I, Batista IFB, Martinhez OCI, Cury Y. Centre of Excellence in New Target Discovery (CENTD): new approach to inflammatory molecular targets and signaling pathways identification. Toxicon. 2019. doi: 10.1016/j.toxicon.2019.06.161.

Cunegundes PS, De Souza JG, Oliveira DS, Chudzinski-Tavassi AM. A new differentiation method for THP-1-Derived Dendritic cells. Toxicon. 2019 Oct 5;168(1) . doi: 10.1016/j.toxicon.2019.06.164.

de Souza JG, Jensen JR, Starobinas N, Monteleone LF, Cabrera WH, Ibañez OC. Pycard gene Polymorphism and pristane induced Arthritis in mice selected for acute inflammatory response. Osteoarthritis and Cartilage. 2019 Apr 1;27(1) . doi: 10.1016/j.joca.2019.02.315.

de Carvalho LR, Borrego A, Jensen JR, Cabrera WHK, Santos AM, Ribeiro OG, Starobinas N, De Franco M, Dragani TA, Manenti G, Ibañez OCM. Genetic Predisposition to Hepatocarcinogenesis in Inbred and Outbred Mouse Lines Selected for High or Low Inflammatory Response. J Immunol Res. 2019 Mar 31;2019:5298792. doi: 10.1155/2019/5298792.

Fernandes JG, Borrego A, Jensen JR, Cabrera WHK, Correa MA, Starobinas N, Ribeiro OG, Ibañez OM, De Franco M. miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. J Immunol Res. 2018 Dec 16;2018:1928405. doi: 10.1155/2018/1928405.

Oliveira FBD, Antoniolli E, Souza JG, Dias OFM, Ferretti M. Mesenchymal stromal cells tracking and cytokines kinetics following intra-articular and intravenous transplantation. Osteoarthritis and Cartilage. 2019 Apr 1;27(1) . doi: 10.1016/j.joca.2019.02.315.

Oliveira FBD, Souza JG, Furiama O, Ferretti M, Antoniolli E. Imaging and functional assessment of medial meniscus surgical destabilization animal model for osteoarthritis. Osteoarthritis and Cartilage. 2018 Apr 1;26(1) . doi: 10.1016/j.joca.2018.02.889.

Pavon LF, Capper D, Sibov TT, de Toledo SRC, Thomale UW, de Souza JG, Cabral FR, Berra CM, Silva da Costa MD, Mendonça Niçacio J, Dastoli PA, de Oliveira DM, Malheiros SMF, da Cruz EF, Malheiros JM, de Oliveira SM, Silva NS, Petrilli AS, Cappellano AM, Brunialti MC, Salomão R, de Paiva Neto MA, Chudzinski-Tavassi AM, Cavalheiro S. New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X. Sci Rep. 2019 Jul 10;9(1):9973. doi: 10.1038/s41598-019-45799-4.

Pavon LF, Sibov TT, de Souza AV, da Cruz EF, Malheiros SMF, Cabral FR, de Souza JG, Boufleur P, de Oliveira DM, de Toledo SRC, Marti LC, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, Chudzinski-Tavassi AM, de Paiva Neto MA, Cavalheiro S. Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo. Stem Cell Res Ther. 2018 Nov 9;9(1):310. doi: 10.1186/s13287-018-1049-0.

Rossato C, Albuquerque LL, Katz ISS, Borrego A, Cabrera WHK, Spadafora-Ferreira M, Ribeiro OG, Starobinas N, Ibañez OM, De Franco M, Jensen JR. Early Peritoneal CC Chemokine Production Correlates with Divergent Inflammatory Phenotypes and Susceptibility to Experimental Arthritis in Mice. J Immunol Res. 2019 Feb 26;2019:2641098. doi: 10.1155/2019/2641098.

Sibov TT, Pavon LF, Cabral FR, Cunha IF, De Oliveira DM, De Souza JG, Marti LC, Da Cruz EF, Malheiros JM, Paiva FF, Tannús A, De Oliveira SM, Da Costa MDS, Dastoli PA, Mendonça JN, De Toledo SRC, Malheiros SMF, De Paiva Neto MA, Rego NBB, Moron AF, Cavalheiro S. Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke. Cell Transplant. Sep-Oct 2019;28(9-10):1306-1320. doi: 10.1177/0963689719854342.

2018

Alvarez-Flores MP, Hébert A, Gouelle C, Geller S, Chudzinski-Tavassi AM, Pellerin L. Neuroprotective effect of rLosac on supplement-deprived mouse cultured cortical neurons involves maintenance of monocarboxylate transporter MCT2 protein levels. J. Neurochemistry. 2019 Jan;148(1):80-96. DOI: 10.1111/jnc.14617. Epub 2018 Dec 3.

Boufleur P, Sciani JM, Goldfeder M, Faria F, Branco V, Chudzinski-Tavassi AM. Biodistribution and Pharmacokinetics of Amblyomin-X, a Novel Antitumour Protein Drug in Healthy Mice. Eur J Drug Metab Pharmacokinet. 2019 Feb;44(1):111-120. DOI: 10.1007/s13318-018-0500-z.

Chudzinski-Tavassi AM, Faria F, Alvarez-Flores MP. Anticoagulants from Hematophagous. In: Božič-Mijovski M, editor. Anticoagulant Drugs. London: Intochopen; 2018 Nov 5. Chapter 3, p. 39-61. DOI: 10.5772/intechopen.78025.

Chudzinski-Tavassi AM, Morais KLP, de Souza JG, Chammas R. Role of Immune System in Kidney Cancer. In: Kommu SS, Gill I, editors. Evolving Trends in Kidney Cancer. London: Intochopen; 2018 Nov 5. DOI: 10.5772/intechopen.77379.

Mambelli-Lisboa NC, Mozer Sciani J, Rossan Brandão Prieto da Silva A, Kerkis I. Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells. Molecules. 2018 Apr 20;23(4):968. DOI: 10.3390/molecules23040968.

Maria DA, Will SEAL, Bosch RV, Souza JG, Sciani JM, Goldfeder MB, Rondon GG, Chudzinski-Tavassi AM. Preclinical evaluation of Amblyomin-X, a Kunitz-type protease inhibitor with antitumor activity. Toxicol Rep. 2018 Dec 1;6:51-63. DOI: 10.1016/j.toxrep.2018.11.014.

Schmidt MCB, Morais KLP, Almeida MES, Iqbal A, Goldfeder MB, Chudzinski-Tavassi AM. Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells. Cell Adh Migr. 2018 Sep 25;14(1):129-138. DOI: 10.1080/19336918.2018.1516982.

Villas-Boas IM, Bonfá G, Tambourgi DV. Venomous caterpillars: From inoculation apparatus to venom composition and envenomation. Toxicon. 2018 Oct;153:39-52. DOI: 10.1016/j.toxicon.2018.08.007.

2017

Iqbal A, Goldfeder MB, Marques-Porto R, Asif H, Souza JG, Faria F, Chudzinski-Tavassi AM. Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin. Sci Rep. 2017 May 3;7(1):1431. DOI: 10.1038/s41598-017-01486-w.

Kerkis I, de Brandão Prieto da Silva AR, Pompeia C, Tytgat J, de Sá Junior PL. Toxin bioportides: exploring toxin biological activity and multifunctionality. Cell Mol Life Sci. 2017 Feb;74(4):647-661. DOI: 10.1007/s00018-016-2343-6.

2016

Branco VG, Iqbal A, Alvarez-Flores MP, Sciani JM, de Andrade SA, Iwai LK, Serrano SM, Chudzinski-Tavassi AM. Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo. Biochim Biophys Acta. 2016 Oct;1864(10):1428-35. DOI: 10.1016/j.bbapap.2016.07.011.

de Souza JG, Morais KL, Anglés-Cano E, Boufleur P, de Mello ES, Maria DA, Origassa CS, de Campos Zampolli H, Câmara NO, Berra CM, Bosch RV, Chudzinski-Tavassi AM. Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model. Oncotarget. 2016 Aug 23. DOI: 10.18632/oncotarget.11555.

     

A guerra contra o câncer no Brasil - Carlos Henrique Fioravant

Instituto Butantan - 15/10/2019

A obra "A Guerra contra o câncer no Brasil" da editora Atheneu mostra que os homens da ciência médica são tradutores de seu tempo, quando olham para as possibilidades de intervir no corpo individual e social para diminuir sofrimentos e encontrar os males que assolam a população.

SINOPSE

Antes era fácil-fácil demais- levar uma molécula nova para testes em hospitais. Agora, a engrenagem entre centros de pesquisa, hospitais, empresas e governo move-se lentamente e com rigor, filtrando erros que poderiam ser prejudiciais à saúde pública.Desde o início do século XX, três brasileiros - dois médicos e um químico - seguiram as regras científicas de desenvolvimento de fármacos, menos rigorosas que as atuais, e criaram medicamentos que foram usados por milhares de pessoas.Depois deles, nenhuma outra molécula biologicamente ativa original contra o câncer nascida em ambientes acadêmicos ou não acadêmicos conseguiu vencer todas as etapas de desenvolvimento e obter a aprovação para o uso amplo.Um dos propósitos deste livro é motivar a reflexão sobre a capacidade criativa de cientistas brasileiros e a importância da articulação entre especialistas de centros de pesquisas biomédicas, órgãos de governo e empresas, de modo que as possibilidades de novos tratamentos que se mostrarem consistentes não sejam perdidas.

Ano: 2019
Assunto: Medicina - Oncologia
Idioma: PORTUGUÊS
Nº de Páginas: 210